Zc3h12a^tm2.1Aki
Targeted Allele Detail

Summary

• Symbol: Zc3h12a^tm2.1Aki
• Name: zinc finger CCCH type containing 12A; targeted mutation 2.1, Shizuo Akira
• MGI ID: MGI:6111396
• Synonyms: Regnase-1^fl
• Gene: Zc3h12a Location: Chr4:125012216-125021633 bp, - strand Genetic Position: Chr4, 58.1 cM
• Alliance: Zc3h12a^tm2.1Aki page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:198415
• Parent Cell Line: GSI-1 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: Exons 4 to 6 were flanked by loxP sites. A loxP-flanked neomycin selection cassette was removed by cre-mediated recombination. (J:198415)

Expression

In Mice Carrying this Mutation:

2 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Zc3h12a Mutation: 33 strains or lines available

References

• Original: J:198415 Uehata T, et al., Malt1-induced cleavage of regnase-1 in CD4(+) helper T cells regulates immune activation. Cell. 2013 May 23;153(5):1036-49
• All: 11 reference(s)