Sub1^tm1.2Ics
Targeted Allele Detail

Summary

• Symbol: Sub1^tm1.2Ics
• Name: SUB1 homolog, transcriptional regulator; targeted mutation 1.2, Mouse Clinical Institute
• MGI ID: MGI:6108891
• Synonyms: PC4^-, Sub1^tm1.1Ics
• Gene: Sub1 Location: Chr15:11981422-11996091 bp, - strand Genetic Position: Chr15, 5.9 cM, cytoband A2
• Alliance: Sub1^tm1.2Ics page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:237051
• Parent Cell Line: S3 (ES Cell)
• Strain of Origin: C57BL/6NCrl

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site and an FRT site flanked neomycin resistance gene cassette were inserted between exon 1a and exon 2. A second loxP site was inserted into intron 2. The neo cassette was removed through subsequent Flp-mediated recombination and exon 2 was deleted through Cre-mediated recombination. (J:237051)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sub1 Mutation: 41 strains or lines available

References

• Original: J:237051 Swaminathan A, et al., Transcriptional Coactivator and Chromatin Protein PC4 Is Involved in Hippocampal Neurogenesis and Spatial Memory Extinction. J Biol Chem. 2016 Sep 23;291(39):20303-14
• All: 1 reference(s)