Bckdk^{tm1b(EUCOMM)Wtsi}
Targeted Allele Detail

Summary

• Symbol: Bckdk^{tm1b(EUCOMM)Wtsi}
• Name: branched chain ketoacid dehydrogenase kinase; targeted mutation 1b, Wellcome Trust Sanger Institute
• MGI ID: MGI:6105931
• Synonyms: BDK-KO
• Gene: Bckdk Location: Chr7:127503245-127508836 bp, + strand Genetic Position: Chr7, 69.82 cM
• Alliance: Bckdk^{tm1b(EUCOMM)Wtsi} page
• IMPC: Bckdk gene page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:241307
• Parent Cell Line: JM8A3.N1 (ES Cell)
• Strain of Origin: C57BL/6N-A^tm1Brd
• Project Collection: EUCOMM

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intergenic deletion
• Mutation details: Cre-mediated excision of the parental Bckdk^{tm1a(EUCOMM)Wtsi} allele resulted in the removal of the promoter-driven neomycin selection cassette and critical exon(s) leaving behind the inserted lacZ reporter sequence. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml. (J:241307)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Bckdk Mutation: 46 strains or lines available

References

• Original: J:241307 Ishikawa T, et al., Muscle-specific deletion of BDK amplifies loss of myofibrillar protein during protein undernutrition. Sci Rep. 2017 Jan 04;7:39825
• All: 2 reference(s)