Wdr47tm1c(EUCOMM)Wtsi
Targeted Allele Detail
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Symbol: |
Wdr47tm1c(EUCOMM)Wtsi |
Name: |
WD repeat domain 47; targeted mutation 1c, Wellcome Trust Sanger Institute |
MGI ID: |
MGI:6102913 |
Gene: |
Wdr47 Location: Chr3:108498595-108553035 bp, + strand Genetic Position: Chr3, 47.38 cM
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Alliance: |
Wdr47tm1c(EUCOMM)Wtsi page
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IMPC: |
Wdr47 gene page |
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Mutant Cell Line: |
EPD0046_1_C04 |
Germline Transmission: |
Earliest citation of germline transmission:
J:249035
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Parent Cell Line: |
JM8.F6 (ES Cell)
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Strain of Origin: |
C57BL/6N
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Project Collection: |
EUCOMM
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Allele Type: |
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Targeted (Conditional ready) |
Mutation: |
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Insertion
Vector: L1L2_gt0
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Mutation details: The L1L2_gt0 cassette was inserted at position 108525343 of Chromosome 3 upstream of the critical exon(s) (Build GRCm39). The cassette is composed of an FRT flanked lacZ/neomycin sequence followed by a loxP site. An additional loxP site is inserted downstream of the targeted exon(s) at position 108526974. The critical exon(s) is/are thus flanked by loxP sites. A "conditional ready" (floxed) allele was created by flp recombinase expression in mice carrying this allele to remove the lacZ sequence and neo selection cassette, leaving loxP sites flanking the critical exon(s).
(J:249035)
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Wdr47 Mutation: |
52 strains or lines available
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Original: |
J:249035 Kannan M, et al., WD40-repeat 47, a microtubule-associated protein, is essential for brain development and autophagy. Proc Natl Acad Sci U S A. 2017 Oct 31;114(44):E9308-E9317 |
All: |
4 reference(s) |
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