Prkn^tm1.1Muqit
Targeted Allele Detail

Summary

• Symbol: Prkn^tm1.1Muqit
• Name: parkin RBR E3 ubiquitin protein ligase; targeted mutation 1.1, Miratul Muqit
• MGI ID: MGI:6099059
• Synonyms: Parkin S65A
• Gene: Prkn Location: Chr17:11059271-12282248 bp, + strand Genetic Position: Chr17, 7.8 cM, cytoband A3.2-A3.3
• Alliance: Prkn^tm1.1Muqit page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:341592
• Parent Cell Line: ART B6 3.6 (ES Cell)
• Strain of Origin: C57BL/6NTac

Mutation description

• Allele Type: Targeted (Not Applicable)
• Mutation: Nucleotide substitutions
• Mutation details: The targeting vector contains an FRT-flanked PuroR selection cassette inserted into intron 2 and an S65A point mutation inserted into exon 3. Flp-mediated recombination removed the FRT-flanked PuroR cassette. (J:341592)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Prkn Mutation: 55 strains or lines available

References

• Original: J:341592 McWilliams TG, et al., Phosphorylation of Parkin at serine 65 is essential for its activation in vivo. Open Biol. 2018 Nov 7;8(11)
• All: 1 reference(s)