Bmp1^tm1Dgr
Targeted Allele Detail

Summary

• Symbol: Bmp1^tm1Dgr
• Name: bone morphogenetic protein 1; targeted mutation 1, David S Greespan
• MGI ID: MGI:6098743
• Gene: Bmp1 Location: Chr14:70711998-70757674 bp, - strand Genetic Position: Chr14, 36.32 cM
• Alliance: Bmp1^tm1Dgr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:210366
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: A loxP-flanked neomycin resistant cassette and a third loxP sitere were inserted upstream of exon 3 and downstream of exon 6 (J:210366)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Bmp1 Mutation: 46 strains or lines available

References

• Original: J:210366 Muir AM, et al., Induced ablation of Bmp1 and Tll1 produces osteogenesis imperfecta in mice. Hum Mol Genet. 2014 Jun 15;23(12):3085-101
• All: 1 reference(s)