Il21^tm1.1Hm
Targeted Allele Detail

Summary

• Symbol: Il21^tm1.1Hm
• Name: interleukin 21; targeted mutation 1.1, Herbert Morse III
• MGI ID: MGI:6095616
• Synonyms: IL21-VFP
• Gene: Il21 Location: Chr3:37276908-37286785 bp, - strand Genetic Position: Chr3, 18.36 cM, cytoband B
• Alliance: Il21^tm1.1Hm page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:248557
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Reporter)
• Mutation: Insertion
• Mutation details: The targeting vector contains an IRES sequence, VFP (vivid Verde fluorescent protein) sequence, and a loxP-flanked PGK-neo cassette inserted into the non-coding region of exon 5. Cre-mediated recombination removed the floxed neo cassette. (J:248557)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 3 strains available Cell Lines: 0 lines available
• Carrying any Il21 Mutation: 42 strains or lines available

References

• Original: J:248557 Marnik EA, et al., Precocious Interleukin 21 Expression in Naive Mice Identifies a Natural Helper Cell Population in Autoimmune Disease. Cell Rep. 2017 Oct 3;21(1):208-221
• All: 6 reference(s)