Srsf9^em1(IMPC)J
Endonuclease-mediated Allele Detail

Summary

• Symbol: Srsf9^em1(IMPC)J
• Name: serine and arginine-rich splicing factor 9; endonuclease-mediated mutation 1, Jackson
• MGI ID: MGI:5925314
• Gene: Srsf9 Location: Chr5:115465236-115471139 bp, + strand Genetic Position: Chr5, 56.05 cM, cytoband F
• Alliance: Srsf9^em1(IMPC)J page
• IMPC: Srsf9 gene page

Mutation origin

• Strain of Origin: C57BL/6NJ
• Project Collection: IMPC

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: This allele was generated at The Jackson Laboratory by injecting Cas9 RNA and 4 guide sequences TCAGTGCTACCCCACAGCCT, GCGAGAGTCACTGAGCAGGG, CATAGGCTGCATTACTTGCA and CTAGCCTTCAAGGAAGTGTG, which resulted in a 285 bp deletion beginning at Chromosome 5 positive strand position 115,330,421 bp and ending after 115,330,705 bp (GRCm38/mm10). This mutation deletes ENSMUSE00001217221 (exon 2) and 124 bp of flanking intronic sequence including the splice acceptor and donor and is predicted to cause a change of amino acid sequence after residue 64 and early truncation 33 amino acids later. (J:188991)
• Inheritance: Not Specified

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Srsf9 Mutation: 20 strains or lines available

References

• Original: J:188991 The Jackson Laboratory, Alleles produced for the KOMP project by The Jackson Laboratory. MGI Direct Data Submission. 2012
• All: 3 reference(s)