Trim30a^tm1Bsun
Targeted Allele Detail

Summary

• Symbol: Trim30a^tm1Bsun
• Name: tripartite motif-containing 30A; targeted mutation 1, Bing Sun
• MGI ID: MGI:5912450
• Synonyms: Trim30alpha^-
• Gene: Trim30a Location: Chr7:104058232-104114400 bp, - strand Genetic Position: Chr7, 55.69 cM
• Alliance: Trim30a^tm1Bsun page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:242804
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 2, which conatins the translation start site, was replaced with a neomycin resistance gene cassette. Immunoblot analysis confirmed the absence of peptide products from this allele in splenocytes. (J:242804)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Trim30a Mutation: 43 strains or lines available

References

• Original: J:242804 Wang Y, et al., TRIM30alpha Is a Negative-Feedback Regulator of the Intracellular DNA and DNA Virus-Triggered Response by Targeting STING. PLoS Pathog. 2015 Jun;11(6):e1005012
• All: 1 reference(s)