Rab6a^tm1.2Ics
Targeted Allele Detail

Summary

• Symbol: Rab6a^tm1.2Ics
• Name: RAB6A, member RAS oncogene family; targeted mutation 1.2, Mouse Clinical Institute
• MGI ID: MGI:5912015
• Gene: Rab6a Location: Chr7:100256778-100290475 bp, + strand Genetic Position: Chr7, 54.36 cM, cytoband C4
• Alliance: Rab6a^tm1.2Ics page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:243756
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of exon 4. An FRT- and loxP-flanked neomycin resistance cassette was inserted downstream of exon 4. Flp-mediated recombination removed the selection cassette. Cre-mediated recombination removed exon 4. Both isoforms are predicted to be knocked out. (J:243756)

Expression

In Mice Carrying this Mutation:	16 assay results
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rab6a Mutation: 25 strains or lines available

References

• Original: J:243756 Bardin S, et al., Phenotypic characterisation of RAB6A knockout mouse embryonic fibroblasts. Biol Cell. 2015 Dec;107(12):427-39
• All: 3 reference(s)