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Targeted Allele Detail
Symbol: Slc22a6tm1.1(cre/ERT2)Amat
Name: solute carrier family 22 (organic anion transporter), member 6; targeted mutation 1.1, Athena Matakidou
MGI ID: MGI:5911847
Synonyms: Slc22a6-CreERT2
Gene: Slc22a6  Location: Chr19:8595403-8605663 bp, + strand  Genetic Position: Chr19, 5.44 cM
Alliance: Slc22a6tm1.1(cre/ERT2)Amat page
Germline Transmission:  Earliest citation of germline transmission: J:243751
Parent Cell Line:  Other (see notes) (ES Cell)
Strain of Origin:  C57BL/6J
Allele Type:    Targeted (Inducible, Recombinase)
Inducer:    tamoxifen
Mutations:    Insertion, Intragenic deletion
Slc22a6tm1.1(cre/ERT2)Amat expression driven by 1 gene
Mutation detailsUsing recombineering methods, the CreERT2-Frt-PGK-Hygromycin-pA-Frt cassette replaced the ATG start codon in exon 1 of the Slc22a6 gene in the BAC clone RP23-457i11. The modified BAC construct was electroporated into ES cells and correctly targeted ES cells were injected into CD1 blastocysts and the resulting chimeric mice were bred to C57BL/6J mice. These mice were then bred to mice containing Flp-recombinase to remove the Frt-flanked hygromycin selection cassette. (J:243751)
 Tissue activity of this recombinase allele
Driver: Slc22a6 (mouse)
Summary of all recombinase alleles driven by Slc22a6.

Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Slc22a6 Mutation:  34 strains or lines available
C57BL/6J embryonic stem cells (CRIB6.1, an ES line derived in house) were used.
Original:  J:243751 Espana-Agusti J, et al., Generation and Characterisation of a Pax8-CreERT2 Transgenic Line and a Slc22a6-CreERT2 Knock-In Line for Inducible and Specific Genetic Manipulation of Renal Tubular Epithelial Cells. PLoS One. 2016;11(2):e0148055
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
MGI 6.24
The Jackson Laboratory