Runx3^tm4.1Yg
Targeted Allele Detail

Summary

• Symbol: Runx3^tm4.1Yg
• Name: runt related transcription factor 3; targeted mutation 4.1, Yoram Groner
• MGI ID: MGI:5911699
• Synonyms: P1^AFP, Runx3-P1-AFP
• Gene: Runx3 Location: Chr4:134847963-134905301 bp, + strand Genetic Position: Chr4, 67.19 cM
• Alliance: Runx3^tm4.1Yg page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:241125
• Parent Cell Line: W4 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Reporter)
• Mutation: Insertion
• Mutation details: An AFP-lox-PGK/neo-lox cassette was inserted at the initiator ATG of the promoter P1-driven transcription unit. The floxed neo cassette was subsequently removed by Cre-mediated recombination. (J:241125)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Runx3 Mutation: 28 strains or lines available

References

• Original: J:241125 Levanon D, et al., Absence of Runx3 expression in normal gastrointestinal epithelium calls into question its tumour suppressor function. EMBO Mol Med. 2011 Oct;3(10):593-604
• All: 6 reference(s)