Gad2^tm1.1Rpa
Targeted Allele Detail

Summary

• Symbol: Gad2^tm1.1Rpa
• Name: glutamic acid decarboxylase 2; targeted mutation 1.1, Richard D Palmiter
• MGI ID: MGI:5911613
• Synonyms: Gad2^lox
• Gene: Gad2 Location: Chr2:22512262-22583889 bp, + strand Genetic Position: Chr2, 15.15 cM, cytoband A-B
• Alliance: Gad2^tm1.1Rpa page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:232044
• Parent Cell Line: G4 (ES Cell)
• Strain of Origin: (129S6/SvEvTac x C57BL/6NCrl)F1

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: Exon 1 was flanked by loxP site and a frt-flanked neo cassette was inserted downstream of exon 1. The neo cassette was removed by Flp-mediated recombination. (J:232044)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gad2 Mutation: 61 strains or lines available

References

• Original: J:232044 Meng F, et al., New inducible genetic method reveals critical roles of GABA in the control of feeding and metabolism. Proc Natl Acad Sci U S A. 2016 Mar 29;113(13):3645-50
• All: 2 reference(s)