Ptprb^tm1Dvst
Targeted Allele Detail

Summary

• Symbol: Ptprb^tm1Dvst
• Name: protein tyrosine phosphatase receptor type B; targeted mutation 1, Dietmar Vestweber
• MGI ID: MGI:5911458
• Synonyms: Ptprb^lox
• Gene: Ptprb Location: Chr10:116111428-116225440 bp, + strand Genetic Position: Chr10, 64.68 cM, cytoband D2
• Alliance: Ptprb^tm1Dvst page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:228935
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 20 and an FRT flanked neo cassette and loxP site were inserted downstream of exon 20 via homologous recombination. (J:228935)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ptprb Mutation: 98 strains or lines available

References

• Original: J:228935 Frye M, et al., Interfering with VE-PTP stabilizes endothelial junctions in vivo via Tie-2 in the absence of VE-cadherin. J Exp Med. 2015 Dec 14;212(13):2267-87
• All: 2 reference(s)