Psmb11^{tm2.1(rtTA)Yout}
Targeted Allele Detail

Summary

• Symbol: Psmb11^{tm2.1(rtTA)Yout}
• Name: proteasome (prosome, macropain) subunit, beta type, 11; targeted mutation 2.1, Yousuke Takahama
• MGI ID: MGI:5911440
• Synonyms: beta5t-rtTA
• Gene: Psmb11 Location: Chr14:54862767-54867013 bp, + strand Genetic Position: Chr14, 27.87 cM
• Alliance: Psmb11^{tm2.1(rtTA)Yout} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:228959
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Transactivator)
• Mutation: Insertion
• Mutation details: An rtTA cassette and FRT flanked PGKK-neo cassette in reverse orientation replaced most of the coding exon via homologous recombination. Flp-mediated recombination removed the neo cassette. (J:228959)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Psmb11 Mutation: 13 strains or lines available

References

• Original: J:228959 Ohigashi I, et al., Adult Thymic Medullary Epithelium Is Maintained and Regenerated by Lineage-Restricted Cells Rather Than Bipotent Progenitors. Cell Rep. 2015 Nov 17;13(7):1432-43
• All: 4 reference(s)