Rnaseh2c^tm1Roer
Targeted Allele Detail

Summary

• Symbol: Rnaseh2c^tm1Roer
• Name: ribonuclease H2, subunit C; targeted mutation 1, Axel Roers
• MGI ID: MGI:5911394
• Gene: Rnaseh2c Location: Chr19:5651901-5652987 bp, + strand Genetic Position: Chr19, 4.34 cM, cytoband A
• Alliance: Rnaseh2c^tm1Roer page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:186986
• Parent Cell Line: JM8.F6 (ES Cell)
• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• A neomycin resistance cassette replaced the 4 coding exons. (J:186986)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rnaseh2c Mutation: 6 strains or lines available

References

• Original: J:186986 Hiller B, et al., Mammalian RNase H2 removes ribonucleotides from DNA to maintain genome integrity. J Exp Med. 2012 Jul 30;209(8):1419-26
• All: 1 reference(s)