Oprk1^{tm1.1(cre)Sros}
Targeted Allele Detail

Summary

• Symbol: Oprk1^{tm1.1(cre)Sros}
• Name: opioid receptor, kappa 1; targeted mutation 1.1, Sarah Ross
• MGI ID: MGI:5910988
• Synonyms: KOR-Cre
• Gene: Oprk1 Location: Chr1:5658689-5676354 bp, + strand Genetic Position: Chr1, 1.89 cM, cytoband A2-A3
• Alliance: Oprk1^{tm1.1(cre)Sros} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:229097
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Recombinase)
• Mutations: Insertion, Intragenic deletion
• Oprk1^{tm1.1(cre)Sros} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Oprk1 (MGI:97439)

• Mutation details: The coding region of the gene in exon 2 was replaced with a Cre recombinase gene followed by a polyadenylation sequence. An Frt-flanked neomycin selection cassette was inserted at the 3' end, but removed by flp-mediated recmobination in the final allele. (J:229097)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Oprk1 (mouse) Summary of all recombinase alleles driven by Oprk1. Comparative matrix view of recombinase activities Alliance mouse Oprk1 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Oprk1 Mutation: 29 strains or lines available

References

• Original: J:229097 Cai X, et al., Generation of a KOR-Cre knockin mouse strain to study cells involved in kappa opioid signaling. Genesis. 2016 Jan;54(1):29-37
• All: 3 reference(s)