Meioc^tm1.1Dcp
Targeted Allele Detail

Summary

• Symbol: Meioc^tm1.1Dcp
• Name: meiosis specific with coiled-coil domain; targeted mutation 1.1, David C Page
• MGI ID: MGI:5910926
• Synonyms: 1lox, Meioc^-, Meioc 1L
• Gene: Meioc Location: Chr11:102556177-102573066 bp, + strand Genetic Position: Chr11, 66.48 cM
• Alliance: Meioc^tm1.1Dcp page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:242348
• Parent Cell Line: v6.5 (ES Cell)
• Strain of Origin: (C57BL/6 x 129S4/SvJae)F1

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: The L1L2_Bact_P cassette was inserted at position 102558690 of Chromosome 11 upstream of the critical exon 3(Build GRCm39). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. A third loxP site is inserted downstream of exon 3 at position 102559518. Flp-mediated recombination removed the FRT-flanked neo cassette. Germ line, cre mediated recombination removed exon 3. The mutation is predicted to result in a frameshift and creates a premature stop codon subsequent to exon 2. (J:242348)

Expression

In Mice Carrying this Mutation:

36 assay results 1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Meioc Mutation: 38 strains or lines available

References

• Original: J:242348 Soh YQS, et al., Meioc maintains an extended meiotic prophase I in mice. PLoS Genet. 2017 Apr;13(4):e1006704
• All: 1 reference(s)