Sox14^{tm2.1(cre)Tmj}
Targeted Allele Detail

Summary

• Symbol: Sox14^{tm2.1(cre)Tmj}
• Name: SRY (sex determining region Y)-box 14; targeted mutation 2.1, Thomas M Jessell
• MGI ID: MGI:5909921
• Synonyms: Sox14::Cre
• Gene: Sox14 Location: Chr9:99756159-99758223 bp, - strand Genetic Position: Chr9, 52.11 cM
• Alliance: Sox14^{tm2.1(cre)Tmj} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:243238
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S/SvEv

Mutation description

• Allele Type: Targeted (Null/knockout, Recombinase)
• Mutations: Insertion, Intragenic deletion
• Sox14^{tm2.1(cre)Tmj} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Sox14 (MGI:98362)

• Mutation details: The targeting vector was constructed by replacing the Sox14 coding sequence with a cassette consisting of a 5' splice substrate followed by the cre gene and a bovine growth hormone polyadenylation signal (bGHpA) followed by a Frt flanked neomycin gene cassette by homologouse recombination in ES cells. The PGKneo cassette was removed after crossing with the FLPeR mice. (J:243238)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Sox14 (mouse) Summary of all recombinase alleles driven by Sox14. Comparative matrix view of recombinase activities Alliance mouse Sox14 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sox14 Mutation: 13 strains or lines available

References

• Original: J:243238 Jager P, et al., Tectal-derived interneurons contribute to phasic and tonic inhibition in the visual thalamus. Nat Commun. 2016 Dec 08;7:13579
• All: 4 reference(s)