Tg(Tcra5/4E8,Tcrb5/4E8)#Wve
Transgene Detail

Summary

• Symbol: Tg(Tcra5/4E8,Tcrb5/4E8)#Wve
• Name: transgene insertion, Willem van Eden
• MGI ID: MGI:5909414
• Synonyms: 5/4E8 TCR
• Transgene: Tg(Tcra5/4E8,Tcrb5/4E8)#Wve Location: unknown
• Alliance: Tg(Tcra5/4E8,Tcrb5/4E8)#Wve page

Transgene origin

• Strain of Origin: (CBA x C57BL/6)F1

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: The transgene contains pre-arranged Tcr loci derived from T cell hydridoma 5/4E8, which recognizes a human proteoglycan epitope (residues 70 ATEGRVRVNSAYQDK 84). The pound symbol (#) is used when no line is specified and/or lines are pooled. (J:132543)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:132543 Berlo SE, et al., Naive transgenic T cells expressing cartilage proteoglycan-specific TCR induce arthritis upon in vivo activation. J Autoimmun. 2005 Nov;25(3):172-80
• All: 4 reference(s)