Tg(TCRA37,TCRB37)TAZ10Sqa
Transgene Detail

Summary

• Symbol: Tg(TCRA37,TCRB37)TAZ10Sqa
• Name: transgene insertion TAZ10, Sonia Quaratino
• MGI ID: MGI:5909310
• Synonyms: TAZ10
• Transgene: Tg(TCRA37,TCRB37)TAZ10Sqa Location: unknown
• Alliance: Tg(TCRA37,TCRB37)TAZ10Sqa page

Transgene origin

• Strain of Origin: (C57BL/6 x CBA)F2

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: The transgene contains prearranged TCR loci from human clone 37, which recognizes the cryptic dominant autoantigen thyroid peroxidase (TPO 536-547). The human-derived extracellular domains were fused to the mouse loci. Founder TAZ10 established the maintained line. (J:132811)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:132811 Quaratino S, et al., Degenerate self-reactive human T-cell receptor causes spontaneous autoimmune disease in mice. Nat Med. 2004 Sep;10(9):920-6
• All: 2 reference(s)