Tg(Stab2-icre)1.2Cger
Transgene Detail

Summary

• Symbol: Tg(Stab2-icre)1.2Cger
• Name: transgene insertion 1.2, Cyrill Geraud
• MGI ID: MGI:5909287
• Synonyms: Stab2-Cre, Stab2^tg1.2cre
• Transgene: Tg(Stab2-icre)1.2Cger Location: unknown
• Alliance: Tg(Stab2-icre)1.2Cger page

Transgene origin

• Strain of Origin: C57BL/6NCrl

Transgene description

• Transgene Type: Transgenic (Recombinase)
• Mutation: Insertion
• Tg(Stab2-icre)1.2Cger expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Stab2 (MGI:2178743)

• Mutation details: A cDNA containing a codon improved version of cre recombinase followed by polyA signal sequence was fused into BAC clone at exon 1 of mouse Stab2 gene so that cre expression is driven by the regulatory sequences of the BAC gene. The resulting modified BAC was used to generate this transgene. Three founder lines 1.1, 1.2, and 1.3 were identified. The line 1.2 displaying cre activity in liver sinusoidal endothelial cells were used for the study. (J:243226)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Stab2 (mouse) Summary of all recombinase alleles driven by Stab2. Comparative matrix view of recombinase activities Alliance mouse Stab2 gene page

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:243226 Geraud C, et al., GATA4-dependent organ-specific endothelial differentiation controls liver development and embryonic hematopoiesis. J Clin Invest. 2017 Mar 01;127(3):1099-1114
• All: 3 reference(s)