Tg(TcraHH8,TcrbHH8)#Jmcc
Transgene Detail

Summary

• Symbol: Tg(TcraHH8,TcrbHH8)#Jmcc
• Name: transgene insertion, James McCluskey
• MGI ID: MGI:5909266
• Synonyms: Valpha8.3 Vbeta8.2
• Transgene: Tg(TcraHH8,TcrbHH8)#Jmcc Location: unknown
• Alliance: Tg(TcraHH8,TcrbHH8)#Jmcc page

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: The transgene contains a pre-arranged Tcr locus from the HH8 hybridoma line (Valpha8.3 and Vbeta8.2) that recognizes the alpha-gliadin 57-73 Q65E (QLQPFPQPELPYPQPQS) epitope. The pound symbol (#) is used when no line is specified and/or lines are pooled. (J:149302)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:149302 de Kauwe AL, et al., Resistance to celiac disease in humanized HLA-DR3-DQ2-transgenic mice expressing specific anti-gliadin CD4+ T cells. J Immunol. 2009 Jun 15;182(12):7440-50
• All: 1 reference(s)