Gabrb3tm2.1Uru
Targeted Allele Detail
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Symbol: |
Gabrb3tm2.1Uru |
Name: |
GABRB3, gamma-aminobutyric acid type A receptor subunit beta 3; targeted mutation 2.1, Uwe Rudolph |
MGI ID: |
MGI:5908395 |
Synonyms: |
S408/9A |
Gene: |
Gabrb3 Location: Chr7:57240266-57478550 bp, + strand Genetic Position: Chr7, 33.53 cM
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Alliance: |
Gabrb3tm2.1Uru page
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Germline Transmission: |
Earliest citation of germline transmission:
J:228332
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Parent Cell Line: |
TC1/TC-1 (ES Cell)
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Strain of Origin: |
129S6/SvEvTac
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Allele Type: |
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Targeted (Not Specified) |
Mutations: |
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Insertion, Nucleotide substitutions
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Mutation details: The codons for serines 408 and 409 in exon 9 were mutated to alanine and a loxP and FRT flanked neo cassette was inserted upstream of the 5' end of exon 9 via homologous recombination. Cre-mediated recombination removed the neo cassette. Cell surface expression of this subunit is increased to 145% of wild-type without modifying total subunit expression levels.
(J:228332)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Gabrb3 Mutation: |
30 strains or lines available
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Original: |
J:228332 Vien TN, et al., Compromising the phosphodependent regulation of the GABAAR beta3 subunit reproduces the core phenotypes of autism spectrum disorders. Proc Natl Acad Sci U S A. 2015 Dec 1;112(48):14805-10 |
All: |
3 reference(s) |
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