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Targeted Allele Detail
Symbol: Krt14tm1.1(cre/ERT2)Hjg
Name: keratin 14; targeted mutation 1.1, Hermann-Josef Grone
MGI ID: MGI:5908393
Synonyms: K14CreERT2, Krt14tm1.1(cre/ERT2)Dkfz
Gene: Krt14  Location: Chr11:100093988-100098336 bp, - strand  Genetic Position: Chr11, 63.43 cM, cytoband D
Alliance: Krt14tm1.1(cre/ERT2)Hjg page
Germline Transmission:  Earliest citation of germline transmission: J:201085
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Inducible, Recombinase)
Inducer:    tamoxifen
Mutation:    Insertion
Krt14tm1.1(cre/ERT2)Hjg expression driven by 1 gene
Mutation detailsAn icre/ERT2 cassette followed by an Frt-flanked neo selection cassette was inserted into downstream of ATG-start codon in frame by homologous recombination in ES cells. Correctly targeted ES cell clones were injected into C57BL/6 blastocyts. Mice were crossed to Flp-expressing mice to delete the neo cassette. (J:201085)
 Tissue activity of this recombinase allele
Driver: Krt14 (mouse)
Summary of all recombinase alleles driven by Krt14.

Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Krt14 Mutation:  37 strains or lines available
Original:  J:201085 Amen N, et al., Differentiation of epidermal keratinocytes is dependent on glucosylceramide:ceramide processing. Hum Mol Genet. 2013 Oct 15;22(20):4164-79
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
MGI 6.13
The Jackson Laboratory