Tacr1tm1.1(cre/ERT2)Sros
Targeted Allele Detail
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Symbol: |
Tacr1tm1.1(cre/ERT2)Sros |
Name: |
tachykinin receptor 1; targeted mutation 1.1, Sarah E Ross |
MGI ID: |
MGI:5908273 |
Synonyms: |
NK1R-CreER |
Gene: |
Tacr1 Location: Chr6:82379315-82537085 bp, + strand Genetic Position: Chr6, 35.94 cM, cytoband D1
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Alliance: |
Tacr1tm1.1(cre/ERT2)Sros page
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Germline Transmission: |
Earliest citation of germline transmission:
J:237538
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Parent Cell Line: |
J1 (ES Cell)
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Strain of Origin: |
129S4/SvJae
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Allele Type: |
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Targeted (Inducible, Null/knockout, Recombinase) |
Inducer: |
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tamoxifen |
Mutations: |
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Insertion, Intragenic deletion
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Tacr1tm1.1(cre/ERT2)Sros expression driven by
1 gene
Knock-in expression driven by:
Organism |
Driver Gene |
Note |
mouse |
Tacr1 (MGI:98475) |
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Mutation details: The coding region of Tacr1 in exon2 was replaced by a cre/ERT2 cassette and a loxP-flanked neo selection cassette by homologous recombination in ES cells. Correctly targeted ES cell clones were injected into C57BL/6 blastocysts. The neo-cassette was deleted by Cre-mediated excision.
(J:237538)
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Activity: |
Tissue activity of this recombinase allele
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Driver:
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Tacr1
(mouse)
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Original: |
J:237538 Huang H, et al., Generation of a NK1R-CreER knockin mouse strain to study cells involved in Neurokinin 1 Receptor signaling. Genesis. 2016 Nov;54(11):593-601 |
All: |
3 reference(s) |
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