Car1tm1.1(cre/ERT2)Cle
Targeted Allele Detail
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Symbol: |
Car1tm1.1(cre/ERT2)Cle |
Name: |
carbonic anhydrase 1; targeted mutation 1.1, Hans Clevers |
MGI ID: |
MGI:5908163 |
Synonyms: |
Car1CreER |
Gene: |
Car1 Location: Chr3:14831274-14873425 bp, - strand Genetic Position: Chr3, 3.18 cM
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Alliance: |
Car1tm1.1(cre/ERT2)Cle page
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Germline Transmission: |
Earliest citation of germline transmission:
J:238627
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Parent Cell Line: |
Not Specified (ES Cell)
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Strain of Origin: |
Not Specified
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Allele Type: |
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Targeted (Inducible, Recombinase) |
Inducer: |
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tamoxifen |
Mutation: |
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Insertion
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Car1tm1.1(cre/ERT2)Cle expression driven by
1 gene
Knock-in expression driven by:
Organism |
Driver Gene |
Note |
mouse |
Car1 (MGI:88268) |
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Mutation details: An IRES-cre/ERT2 cassette followed by a Frt-flanked neo-selection cassette was inserted into exon 7 of the Car1 gene by homologous recombination in ES cells. Correctly targeted ES cell clones were injected into C57BL/6 blastocysts. Mice were crossed to Flp-expressing mice to delete the neo cassette.
(J:238627)
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Activity: |
Tissue activity of this recombinase allele
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Driver:
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Car1
(mouse)
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Car1 Mutation: |
11 strains or lines available
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Original: |
J:238627 Tetteh PW, et al., Generation of an inducible colon-specific Cre enzyme mouse line for colon cancer research. Proc Natl Acad Sci U S A. 2016 Oct 18;113(42):11859-11864 |
All: |
1 reference(s) |
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