Il18bp^em1Flv
Endonuclease-mediated Allele Detail

Summary

• Symbol: Il18bp^em1Flv
• Name: interleukin 18 binding protein; endonuclease-mediated mutation 1, Richard A Flavell
• MGI ID: MGI:5908105
• Gene: Il18bp Location: Chr7:101664092-101667897 bp, - strand Genetic Position: Chr7, 54.71 cM, cytoband F1
• Alliance: Il18bp^em1Flv page

Mutation origin

• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• A 2.5kb deletion encompassing the entire coding region was created using CRISPR/Cas9. (J:227990)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Il18bp Mutation: 17 strains or lines available

References

• Original: J:227990 Nowarski R, et al., Epithelial IL-18 Equilibrium Controls Barrier Function in Colitis. Cell. 2015 Dec 3;163(6):1444-56
• All: 3 reference(s)