Arl13b^{tm1c(EUCOMM)Wtsi}
Targeted Allele Detail

Summary

• Symbol: Arl13b^{tm1c(EUCOMM)Wtsi}
• Name: ADP-ribosylation factor-like 13B; targeted mutation 1c, Wellcome Trust Sanger Institute
• MGI ID: MGI:5907220
• Synonyms: Arl13b^flox
• Gene: Arl13b Location: Chr16:62614048-62667403 bp, - strand Genetic Position: Chr16, 36.43 cM, cytoband C1.2
• Alliance: Arl13b^{tm1c(EUCOMM)Wtsi} page
• IMPC: Arl13b gene page

Mutation origin

• Mutant Cell Line: EPD0065_5_C03
• Germline Transmission: Earliest citation of germline transmission: J:240795
• Parent Cell Line: JM8.F6 (ES Cell)
• Strain of Origin: C57BL/6N
• Project Collection: EUCOMM

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion Vector: L1L2_gt1
• Mutation details: The L1L2_gt1 cassette was inserted at position 62647276 of Chromosome 16 upstream of the critical exon (exon 3) (Build GRCm39). The cassette is composed of an FRT flanked lacZ/neomycin sequence followed by a loxP site. An additional loxP site is inserted downstream of exon 3 at position 62648425. A "conditional ready" (floxed) allele was created by flp recombinase expression in mice carrying this allele to remove the lacZ sequence and neo selection cassette, leaving exon 3 flanked by loxP sites. (J:240795)

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Arl13b Mutation: 22 strains or lines available

References

• Original: J:240795 Li Y, et al., Deletion of ADP Ribosylation Factor-Like GTPase 13B Leads to Kidney Cysts. J Am Soc Nephrol. 2016 Dec;27(12):3628-3638
• All: 2 reference(s)