Gabrr1^em1Rah
Endonuclease-mediated Allele Detail

Summary

• Symbol: Gabrr1^em1Rah
• Name: gamma-aminobutyric acid type A receptor subunit rho 1; endonuclease-mediated mutation 1, R Adron Harris
• MGI ID: MGI:5907202
• Synonyms: rho1 (T6'Y)
• Gene: Gabrr1 Location: Chr4:33132556-33163606 bp, + strand Genetic Position: Chr4, 14.68 cM
• Alliance: Gabrr1^em1Rah page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Not Applicable)
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: A single stranded oligonucleotide introduces the ACC to TAT nucleotide substitutions (resulting in the T298Y amino acid substitution) and a silent single base substitution (C to T) in codon 301 (for genotyping) into the Gabrr1 gene. (J:242963)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Gabrr1 Mutation: 34 strains or lines available

References

• Original: J:242963 Blednov YA, et al., Mutation of the inhibitory ethanol site in GABAA rho1 receptors promotes tolerance to ethanol-induced motor incoordination. Neuropharmacology. 2017 Sep 01;123:201-209
• All: 1 reference(s)