Tbx4^tm1.1Dbm
Targeted Allele Detail

Summary

• Symbol: Tbx4^tm1.1Dbm
• Name: T-box 4; targeted mutation 1.1, Douglas B Menke
• MGI ID: MGI:5907129
• Synonyms: Tbx4 DelB
• Gene: Tbx4 Location: Chr11:85777248-85806923 bp, + strand Genetic Position: Chr11, 51.42 cM
• Alliance: Tbx4^tm1.1Dbm page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:226693
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: (C57BL/6 x 129S/SvEv)F1

Mutation description

• Allele Type: Targeted (Modified regulatory region)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A 732 bp region (mm10: chr11:85,963,353-85,964,084) containing the hind limb enhancer B sequence was replaced with loxP and FRT flanked orthologous sequence from Anolis and a neo cassette. Cre mediated recombination removed the Anolis sequence and the neo cassette. (J:226693)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tbx4 Mutation: 22 strains or lines available

References

• Original: J:226693 Infante CR, et al., Shared Enhancer Activity in the Limbs and Phallus and Functional Divergence of a Limb-Genital cis-Regulatory Element in Snakes. Dev Cell. 2015 Oct 12;35(1):107-19
• All: 1 reference(s)