Vps13c^tm1.1Geno
Targeted Allele Detail

Summary

• Symbol: Vps13c^tm1.1Geno
• Name: vacuolar protein sorting 13C; targeted mutation 1.1, Genoway
• MGI ID: MGI:5907128
• Synonyms: Vps13c^fl
• Gene: Vps13c Location: Chr9:67747678-67902920 bp, + strand Genetic Position: Chr9, 36.77 cM
• Alliance: Vps13c^tm1.1Geno page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:241413
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: LoxP sites were inserted upstream of exon 1 and in intron 1. This creates a conditional-ready allele with exon 1 floxed. Exon 1 contains the translation start site and its deletion would create a null allele. An FRT site flanked neomycin resistance gene cassette that was inserted into intron 1 was removed through flp-mediated recombination. (J:241413)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Vps13c Mutation: 168 strains or lines available

References

• Original: J:241413 Mehta ZB, et al., Changes in the expression of the type 2 diabetes-associated gene VPS13C in the beta-cell are associated with glucose intolerance in humans and mice. Am J Physiol Endocrinol Metab. 2016 Aug 01;311(2):E488-507
• All: 1 reference(s)