Akap5^tm4.1Jsco
Targeted Allele Detail

Summary

• Symbol: Akap5^tm4.1Jsco
• Name: A kinase anchor protein 5; targeted mutation 4.1, John D Scott
• MGI ID: MGI:5907027
• Synonyms: AKAP150 delta C
• Gene: Akap5 Location: Chr12:76371665-76380927 bp, + strand Genetic Position: Chr12, 33.73 cM
• Alliance: Akap5^tm4.1Jsco page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:242891
• Parent Cell Line: G4 (ES Cell)
• Strain of Origin: (129S6/SvEvTac x C57BL/6NCrl)F1

Mutation description

• Allele Type: Targeted (Not Applicable)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The targeting vector is designed to delete residues 31-52, removing the PKC binding domain. A loxP-flanked PGK-neomycin-bGHpA (bovine growth hormone) cassette is placed upstream of the targeted area. Cre-mediated recombination removed the upstream floxed neo cassette. (J:242891)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Akap5 Mutation: 30 strains or lines available

References

• Original: J:242891 Nystoriak MA, et al., Ser1928 phosphorylation by PKA stimulates the L-type Ca2+ channel CaV1.2 and vasoconstriction during acute hyperglycemia and diabetes. Sci Signal. 2017 Jan 24;10(463)
• All: 1 reference(s)