Tg(Prnp-PFN1)850Kiaei
Transgene Detail

Summary

• Symbol: Tg(Prnp-PFN1)850Kiaei
• Name: transgene insertion 850, Mahmoud Kiaei
• MGI ID: MGI:5906305
• Synonyms: hPFN1^WT
• Transgene: Tg(Prnp-PFN1)850Kiaei Location: unknown
• Alliance: Tg(Prnp-PFN1)850Kiaei page

Transgene origin

• Strain of Origin: C57BL/6N

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(Prnp-PFN1)850Kiaei expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  PFN1 (5216)

  Pfn1	(MGI:97549)

• Mutation details: The transgenic construct contains an untagged human profilin 1 (PFN1) cDNA sequence (420 bp) under the direction of mouse prion protein promoter. Expression is detected in brain, spinal cord, and to a lesser extent in skeletal muscle. The transgene is not expressed in the liver. Founder line 850 was identified with total PFN1 protein levels in spinal cord at ~4-fold greater levels compared to endogenous mouse PFN1 protein levels in non-transgenic mice. (J:241428)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:241428 Fil D, et al., Mutant Profilin1 transgenic mice recapitulate cardinal features of motor neuron disease. Hum Mol Genet. 2017 Feb 15;26(4):686-701
• All: 2 reference(s)