Sike1^em1(IMPC)J
Endonuclease-mediated Allele Detail

Summary

• Symbol: Sike1^em1(IMPC)J
• Name: suppressor of IKBKE 1; endonuclease-mediated mutation 1, Jackson
• MGI ID: MGI:5905812
• Gene: Sike1 Location: Chr3:102903056-102911230 bp, + strand Genetic Position: Chr3, 45.25 cM, cytoband F3
• Alliance: Sike1^em1(IMPC)J page
• IMPC: Sike1 gene page

Mutation origin

• Strain of Origin: C57BL/6NJ
• Project Collection: IMPC

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: This allele was generated at The Jackson Laboratory using Cas9 and guides with spacer sequences AGCAGAGTTGAATTGTTAGA, CCAGGGGTGGACGCTGCGGG, CTGATTTATCTTGGTCTGGA, and GGGAGTGACCACATACCAAA that targeted exon(s) ENSMUSE00000173642.4. This resulted in deletion(s) of 27 bp (location: Chr3:102903846-102903872; GRCm39), 545 bp (location: Chr3:102903287-102903831; GRCm39). This description was generated automatically. Additional molecular information including FASTA sequence support for this allele can be found here: (IMPC Gene page) and viewed in a genome context here: (IMPC Genome Browser). (J:384794)

• Inheritance: Not Specified

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Sike1 Mutation: 16 strains or lines available

References

• Original: J:188991 The Jackson Laboratory, Alleles produced for the KOMP project by The Jackson Laboratory. MGI Direct Data Submission. 2012
• All: 3 reference(s)