Tg(Myh6-Pln*)#Egk
Transgene Detail

Summary

• Symbol: Tg(Myh6-Pln*)#Egk
• Name: transgene insertion, Evangelia G Kranias
• MGI ID: MGI:5905137
• Synonyms: PLN-R14Del
• Transgene: Tg(Myh6-Pln*)#Egk Location: unknown
• Alliance: Tg(Myh6-Pln*)#Egk page

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(Myh6-Pln*)#Egk expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  PLN (5350)

  Pln	(MGI:97622)

  arginine 14 is deleted

• Mutation details: The alpha-myosin heavy chain promoter drives cardiac-specific expression of the mouse phospolamban coding region containing a deletion of arginine 14 (AGA deletion mutation). This mutation is found in a family with dilated cardiomyopathy. The pound symbol is used when no line is specified and/or lines are pooled. (J:105976)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:105976 Haghighi K, et al., A mutation in the human phospholamban gene, deleting arginine 14, results in lethal, hereditary cardiomyopathy. Proc Natl Acad Sci U S A. 2006 Jan 31;103(5):1388-93
• All: 2 reference(s)