Pecam1^tm1.1Pnew
Targeted Allele Detail

Summary

• Symbol: Pecam1^tm1.1Pnew
• Name: platelet/endothelial cell adhesion molecule 1; targeted mutation 1.1, Peter Newman
• MGI ID: MGI:5904825
• Synonyms: PECAM1^flox
• Gene: Pecam1 Location: Chr11:106545039-106606107 bp, - strand Genetic Position: Chr11, 69.92 cM, cytoband F3-G1
• Alliance: Pecam1^tm1.1Pnew page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:285796
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A targeting vector was designed to insert a loxP site upstream of exon 1 and a frt-flanked neomycin resistance (neo) cassette, followed by a second loxP site, downstream of exon 2. Flp-mediated recombination deleted the neo cassette. (J:285796)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Pecam1 Mutation: 227 strains or lines available

References

• Original: J:285796 Zhi H, et al., Generation of PECAM-1 (CD31) conditional knockout mice. Genesis. 2020 Feb;58(2):e23346
• All: 1 reference(s)