Gorasp2^tm1.1Maal
Targeted Allele Detail

Summary

• Symbol: Gorasp2^tm1.1Maal
• Name: golgi reassembly stacking protein 2; targeted mutation 1.1, Michel Aurrand-Lions
• MGI ID: MGI:5904163
• Gene: Gorasp2 Location: Chr2:70491520-70522069 bp, + strand Genetic Position: Chr2, 41.82 cM
• Alliance: Gorasp2^tm1.1Maal page

Defective spermatogenesis and acrosome formation in Gorasp2^tm1.1Maal/Gorasp2^tm1.1Maal mice

Show the 2 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:241919
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

Allele Type: Targeted (Null/knockout) Mutations: Insertion, Intragenic deletion Mutation details: The targeting vector consists of a diphtheria toxin A-negative selection cassette (DTA) followed by exons 3 to 6 flanked by loxP sites and a neomycin-positive selection cassette (NeoR) flanked by frt sites downstream of exon 6 but before the loxP site. Cre-mediated recombination removed exons 3-6 and the NeoR cassette. (J:241919)

Generation of the Gorasp2^tm1.1Maal allele

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gorasp2 Mutation: 31 strains or lines available

References

• Original: J:241919 Cartier-Michaud A, et al., Genetic, structural, and chemical insights into the dual function of GRASP55 in germ cell Golgi remodeling and JAM-C polarized localization during spermatogenesis. PLoS Genet. 2017 Jun;13(6):e1006803
• All: 2 reference(s)