Tg(tetO-EGFP/Tfrc*R649H)1Mkgf
Transgene Detail

Summary

• Symbol: Tg(tetO-EGFP/Tfrc*R649H)1Mkgf
• Name: transgene insertion 1, Michael K Georgieff
• MGI ID: MGI:5903118
• Synonyms: Tg(TRE2-eGFP-DNTfR1)Mkg1, TRE-eGFP-DNTfR1
• Transgene: Tg(tetO-EGFP/Tfrc*R649H)1Mkgf Location: unknown
• Alliance: Tg(tetO-EGFP/Tfrc*R649H)1Mkgf page

Transgene origin

• Strain of Origin: C57BL/6J

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence, Reporter)
• Mutation: Insertion
• Mutation details: The transgene contains an EGFP inserted upstream and in frame of the mouse Tfrc gene with a G to A point mutation that results in the amino acid substitution of histidine for arginine at position 649 (R649H). Three lines were generated with line 1 designated as the representative line. This substitution is predicted to produce a dominant negative protein. (J:241563)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:241563 Fretham SJ, et al., Temporal manipulation of transferrin-receptor-1-dependent iron uptake identifies a sensitive period in mouse hippocampal neurodevelopment. Hippocampus. 2012 Aug;22(8):1691-702
• All: 1 reference(s)