Gt(ROSA)26Sor^{tm1(CAG-S1pr1)Thla}
Targeted Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^{tm1(CAG-S1pr1)Thla}
• Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1,Timothy Hla
• MGI ID: MGI:5903055
• Synonyms: S1pr1^f/s/f, S1pr1^f/stop/f
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^{tm1(CAG-S1pr1)Thla} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:189009
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: BALB/cJ

Mutation description

• Allele Type: Targeted (Conditional ready, Inserted expressed sequence)
• Mutation: Insertion
• Gt(ROSA)26Sor^{tm1(CAG-S1pr1)Thla} expresses 1 gene
  Knock-in expresses:
  

  Organism	Expressed Gene	Note
  mouse	S1pr1 (MGI:1096355)

• Mutation details: A transgenic construct containing an FRT3 site, CAG promoter, floxed STOP cassette, mouse S1pr1 sequence, tkNEO cassette and an FRT site, is inserted into the Gt(ROSA)26Sor locus. (J:189009)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 944 strains or lines available

References

• Original: J:189009 Jung B, et al., Flow-regulated endothelial S1P receptor-1 signaling sustains vascular development. Dev Cell. 2012 Sep 11;23(3):600-10
• All: 5 reference(s)