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Fgfr2tm2.1Sor
Targeted Allele Detail
Summary
Symbol: Fgfr2tm2.1Sor
Name: fibroblast growth factor receptor 2; targeted mutation 2.1, Philippe Soriano
MGI ID: MGI:5903019
Synonyms: Fgfr2-mCherry, Fgfr2-T2A-H2B-mCherry
Gene: Fgfr2  Location: Chr7:129764181-129868538 bp, - strand  Genetic Position: Chr7, 73.19 cM
Alliance: Fgfr2tm2.1Sor page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:241560
Parent Cell Line:  AK7.1 (ES Cell)
Strain of Origin:  129S4/SvJaeSor
Mutation
description
Allele Type:    Targeted (No functional change, Reporter)
Mutation:    Insertion
 
Mutation detailsThe targeting vector is designed to replace the stop codon in exon 19 of the Fgfr2 gene with a cassette containing a human HIST1H2BB gene [histone 1 H2bb] sequence, a viral 2A oligopeptide (T2A) that mediates ribosomal skipping, a red fluorescent protein (mCherry) sequence, and a new stop codon. An FRT-flanked neomycin resistance (neo) cassette was inserted in the intron upstream of exon 19. Flp-mediated recombination removed the FRT-flanked neo cassette. (J:241560)
Expression
In Mice Carrying this Mutation: 15 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Fgfr2 Mutation:  88 strains or lines available
References
Original:  J:241560 Molotkov A, et al., Distinct Requirements for FGFR1 and FGFR2 in Primitive Endoderm Development and Exit from Pluripotency. Dev Cell. 2017 Jun 05;41(5):511-526.e4
All:  7 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
05/14/2024
MGI 6.23
The Jackson Laboratory