Tug1^tm1.1Vlcg
Targeted Allele Detail

Summary

• Symbol: Tug1^tm1.1Vlcg
• Name: taurine upregulated gene 1; targeted mutation 1.1, Velocigene
• MGI ID: MGI:5902984
• Gene: Tug1 Location: Chr11:3589313-3599021 bp, - strand Genetic Position: Chr11, 2.56 cM
• Alliance: Tug1^tm1.1Vlcg page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:204277
• Parent Cell Line: VGF1 (ES Cell)
• Strain of Origin: (129S6/SvEvTac x C57BL/6NTac)F1

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Homologous recombination replaced the entire 9 kb gene with a lacZ reporter cassette (including Kozak sequence and ATG start codon) and a loxP site flanked neomycin resistance gene cassette. Cre-mediated recombination removed the floxed neo cassette. (J:204277)

Expression

In Mice Carrying this Mutation:

5 assay results 2 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tug1 Mutation: 10 strains or lines available

Notes

The version of this allele that contains the neomycin selection cassette, Tug1^tm1Vlcg, has been analyzed.

References

• Original: J:204277 Sauvageau M, et al., Multiple knockout mouse models reveal lincRNAs are required for life and brain development. Elife. 2013;2(0):e01749
• All: 2 reference(s)