Tg(Lck-Mirc2)#Mlf
Transgene Detail

Summary

• Symbol: Tg(Lck-Mirc2)#Mlf
• Name: transgene insertion, Matthew L Fero
• MGI ID: MGI:5902473
• Synonyms: Lx, Tg(Lck-Kis2)#Mlf, Tg(Lck-Xpcl1)#Mlf
• Transgene: Tg(Lck-Mirc2)#Mlf Location: unknown
• Alliance: Tg(Lck-Mirc2)#Mlf page

Transgene origin

• Strain of Origin: (C57BL/6J x CBA)F2

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Lck-Mirc2)#Mlf expresses 6 genes
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Mir18b (MGI:3718454)
  mouse	Mir19b-2 (MGI:2676868)
  mouse	Mir20b (MGI:3618748)
  mouse	Mir92-2 (MGI:3619438)
  mouse	Mir106a (MGI:3619120)
  mouse	Mir363 (MGI:3619370)

• Mutation details: The promoter drives T cell-specific expression of a 1.5 kb fragment contained the entire microRNA cluster (Mir363, Mir92-2, Mir19b-2, Mir20b, Mir18b and Mir106a). Two founders were generated. (J:169997, J:243704)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:243704 Kuppers DA, et al., The miR-106a~363Xpcl1 miRNA cluster induces murine T cell lymphoma despite transcriptional activation of the p27Kip1 cell cycle inhibitor. Oncotarget. 2017 Aug 01;8(31):50680-50691
• All: 2 reference(s)