Ube2o^hem9
Chemically induced Allele Detail

Summary

• Symbol: Ube2o^hem9
• Name: ubiquitin-conjugating enzyme E2O; haematopoietic 9
• MGI ID: MGI:5902131
• Synonyms: hem9, Ube2o^E1121X
• Gene: Ube2o Location: Chr11:116428566-116472273 bp, - strand Genetic Position: Chr11, 81.42 cM
• Alliance: Ube2o^hem9 page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Chemically induced (ENU) (Null/knockout)
• Mutation: Nucleotide substitutions
• Mutation details: This allele was identified in a screen for a metabolic and haematopoietic phenotype described as hypochromic, microcytic anemia associated with erythrocytosis using ENU-treated C57BL/6J males (G0). Sequencing identified a G to T substitution, resulting in a E1121X (changing glutamic acid to a termination codon) mutation in the Ube2o gene. The mutation causes truncation of the C-terminal 168 amino acids and is a loss-of-function mutation. No gene product (protein) is detected by western blot analysis of blood. (J:243727)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ube2o Mutation: 57 strains or lines available

References

• Original: J:243727 Nguyen AT, et al., UBE2O remodels the proteome during terminal erythroid differentiation. Science. 2017 Aug 04;357(6350)
• All: 1 reference(s)