Bdkrb2^tm1.1Eldr
Targeted Allele Detail

Summary

• Symbol: Bdkrb2^tm1.1Eldr
• Name: bradykinin receptor, beta 2; targeted mutation 1.1, Samir El-Dahr
• MGI ID: MGI:5898336
• Synonyms: Bdkrb2^flox
• Gene: Bdkrb2 Location: Chr12:105529485-105561496 bp, + strand Genetic Position: Chr12, 55.76 cM
• Alliance: Bdkrb2^tm1.1Eldr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:241281
• Parent Cell Line: iTL IC1 (ES Cell)
• Strain of Origin: C57BL/6NTac

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site is inserted in intron 2 and an FRT-loxP-neomycin-FRT-loxP cassette was introduced to intron 3. Flp-mediated recombination removed the FRT-flanked neo cassette leaving exon 3 floxed. (J:241281)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Bdkrb2 Mutation: 27 strains or lines available

References

• Original: J:241281 Kopkan L, et al., Conditional knockout of collecting duct bradykinin B2 receptors exacerbates angiotensin II-induced hypertension during high salt intake. Clin Exp Hypertens. 2016;38(1):1-9
• All: 2 reference(s)