About   Help   FAQ
Rabep2em1Jef
Endonuclease-mediated Allele Detail
Summary
Symbol: Rabep2em1Jef
Name: rabaptin, RAB GTPase binding effector protein 2; endonuclease-mediated mutation 1, Jefferson Y Chan
MGI ID: MGI:5897807
Synonyms: DelG
Gene: Rabep2  Location: Chr7:126027596-126045079 bp, + strand  Genetic Position: Chr7, 69.03 cM
Alliance: Rabep2em1Jef page
Mutation
origin
Strain of Origin:  C57BL/6
Mutation
description
Allele Type:    Endonuclease-mediated (Null/knockout)
Mutation:    Intragenic deletion
 
Mutation details CRISPR/Cas technology targeting is used to introduce a 1 nucleotide deletion resulting in a guanine deletion (DelG) at rs33080487 in the Rabep2 gene. Immunoblot of the adult brain found undectectable gene expression. (J:241068)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Rabep2 Mutation:  40 strains or lines available
References
Original:  J:241068 Lucitti JL, et al., Variants of Rab GTPase-Effector Binding Protein-2 Cause Variation in the Collateral Circulation and Severity of Stroke. Stroke. 2016 Dec;47(12):3022-3031
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
05/21/2024
MGI 6.23
The Jackson Laboratory