Brs3^{tm1.1(cre/GFP)Rpa}
Targeted Allele Detail

Summary

• Symbol: Brs3^{tm1.1(cre/GFP)Rpa}
• Name: bombesin-like receptor 3; targeted mutation 1.1, Richard D Palmiter
• MGI ID: MGI:5896306
• Synonyms: BRS3-IRES-Cre
• Gene: Brs3 Location: ChrX:56088434-56094118 bp, + strand Genetic Position: ChrX, 30.78 cM, cytoband A7.1-A7.2
• Alliance: Brs3^{tm1.1(cre/GFP)Rpa} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:308449
• Parent Cell Line: G4 (ES Cell)
• Strain of Origin: (129S6/SvEvTac x C57BL/6NCrl)F1

Mutation description

• Allele Type: Targeted (Recombinase, Reporter)
• Mutation: Insertion
• Brs3^{tm1.1(cre/GFP)Rpa} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Brs3 (MGI:1100501)

• Mutation details: IRES-Myc tag-nuclear localization signal (NLS)-cre-GFP-frt-neomycin-frt were introduced just after the termination codon of the X-linked mouse Brs3 gene via homologous recombination. The neomycin cassette was excised through crosses with animals broadly expressing Flp recombinase. (J:101977, J:308449)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Brs3 (mouse) Summary of all recombinase alleles driven by Brs3. Comparative matrix view of recombinase activities Alliance mouse Brs3 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Brs3 Mutation: 14 strains or lines available

References

• Original: J:308449 Mogul AS, et al., Cre recombinase driver mice reveal lineage-dependent and -independent expression of Brs3 in the mouse brain. eNeuro. 2021 Jul 29;:ENEURO.0252-21.2021
• All: 3 reference(s)