Morc3^M1Apb
Chemically induced Allele Detail

Summary

• Symbol: Morc3^M1Apb
• Name: microrchidia 3; mutation 1, Australian Phenomics Facility
• MGI ID: MGI:5883280
• Synonyms: Morc3^mut
• Gene: Morc3 Location: Chr16:93629009-93672961 bp, + strand Genetic Position: Chr16, 54.88 cM
• Alliance: Morc3^M1Apb page

Mutation origin

• Strain of Origin: C57BL/6JAnu

Mutation description

• Allele Type: Chemically induced (ENU) (Dominant negative)
• Mutation: Single point mutation
• Mutation details: An ENU-induced point mutation caused a T to C substitution in base pair 6 of the splice donor site in intron 10. Heterozygotes show an extra splice variant that skips exon 10. (J:71802, J:240210)
• Inheritance: Dominant

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Morc3 Mutation: 78 strains or lines available

References

• Original: J:240210 Jadhav G, et al., Morc3 mutant mice exhibit reduced cortical area and thickness, accompanied by altered haematopoietic stem cells niche and bone cell differentiation. Sci Rep. 2016 May 18;6:25964
• All: 2 reference(s)