Tg(tetO-Tgfbr1*,-EGFP)3Twc
Transgene Detail

Summary

• Symbol: Tg(tetO-Tgfbr1*,-EGFP)3Twc
• Name: transgene insertion 3, Tony Wyss-Coray
• MGI ID: MGI:5882736
• Synonyms: tetO-Alk5^Ctrl
• Transgene: Tg(tetO-Tgfbr1*,-EGFP)3Twc Location: unknown
• Alliance: Tg(tetO-Tgfbr1*,-EGFP)3Twc page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Constitutively active, Inducible, Inserted expressed sequence, Reporter)
• Inducer: doxycycline/tetracycline
• Mutation: Insertion
• Tg(tetO-Tgfbr1*,-EGFP)3Twc expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  rat

  Tgfbr1 (29591)

  Tgfbr1

  (MGI:98728)

  T204D mutation

• Mutation details: The transgene is designed with a bidirectional tetracycline operator between two cytomegalovirus (CMV) minimal promoters in the opposite orientation. One CMV promoter drives expression of hemagglutinin (HA)-tagged, modified rat transforming growth factor, beta receptor I gene, while the other drives expression of an enhanced green fluorescent protein sequence. Tgfbr1 is made constitutively active by the introduction of a T204D mutation. (J:213201)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:213201 He Y, et al., ALK5-dependent TGF-beta signaling is a major determinant of late-stage adult neurogenesis. Nat Neurosci. 2014 Jul;17(7):943-52
• All: 1 reference(s)