Tg(tetO-Tgfbr2*)5Twc
Transgene Detail

Summary

• Symbol: Tg(tetO-Tgfbr2*)5Twc
• Name: transgene insertion 5, Tony Wyss-Coray
• MGI ID: MGI:5882731
• Synonyms: tetO-TbetaRIIdeltak
• Transgene: Tg(tetO-Tgfbr2*)5Twc Location: unknown
• Alliance: Tg(tetO-Tgfbr2*)5Twc page

Transgene origin

• Strain of Origin: 129

Transgene description

• Transgene Type: Transgenic (Inducible, Inserted expressed sequence)
• Inducer: doxycycline/tetracycline
• Mutation: Insertion
• Tg(tetO-Tgfbr2*)5Twc expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  rat

  Tgfbr2 (81810)

  Tgfbr2

  (MGI:98729)

  truncated to delete the transmembrane and intracellular domains

• Mutation details: The transgenic construct contains a mutated rat transforming growth factor, beta receptor II cDNA driven by the tetracycline operator (tetO). The Tgfbr2 cDNA contains a truncation mutation, resulting in a complete deletion of the transmembrane and intracellular domains. (J:114572)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:114572 Tesseur I, et al., Deficiency in neuronal TGF-beta signaling promotes neurodegeneration and Alzheimer's pathology. J Clin Invest. 2006 Nov;116(11):3060-9
• All: 3 reference(s)